DIFFERENTIAL DOPAMINE D1 AND D3 RECEPTOR MODULATION AND EXPRESSION IN THE SPINAL CORD OF TWO MOUSE MODELS OF RESTLESS LEGS SYNDROME

Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome

Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS patients.In contrast, genome-wide association studies in RLS patients have established that a mutation of the MEIS1 gene is associate

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A copula based representation for tailings dam failures

In this article, we model the dependence between dam factor and D max, where dam factor is an indicator of risk of a tailings dam failure, which involves the height H of the tailings dam, the volume of material housed by the Cyclist Accessories - Triathlon - Mens Triathlon tailings dam VT and the volume dispensed by the tailings dam, VF, when the d

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Male Breast Cancer: Current Scenario and Future Perspectives

Male breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%.Since the last 10 years, the incidence has been increased from 7.2% to 10.3% and the mortality rate was decreased from 11% to 3.8%.Nevertheless, the rate of diagnoses has be

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